Clinical effect observation of stomach-tonifying decoction combined with western medicine on the treatment of patients with yin deficiency syndrome of stomach of chronic atrophic gastritis
10.7619/jcmp.201807013
- VernacularTitle:滋胃饮联合西药治疗慢性萎缩性胃炎胃阴亏虚证的临床疗效观察
- Author:
Xiaowei JIA
1
;
Liang YAN
;
Lizhong GUO
Author Information
1. 陕西省延安市中医医院内二科
- Keywords:
chronic atrophic gastritis;
yin deficiency syndrome of stomach;
stomach-tonifying decoction;
inflammatory factors;
immune function;
gastric mucosa;
score of TCM syndromes
- From:
Journal of Clinical Medicine in Practice
2018;22(7):48-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect of stomach-tonifying decoction combined with western medicine on the treatment of patients with yin deficiency syndrome of stomach of chronic atrophic gastritis.Methods Totally 68 patients with yin deficiency syndrome of stomach of chronic atrophic gastritis were randomly divided into control group (n =33) and treatment group (n =35).The control group was treated with western medicines such as amoxicillin capsules,clarithromycin sustained release tablets,omeprazole enteric-coated capsules and bismuth potassium citrate capsules.The treatment group was treated with stomach-tonifying decoction on the basis of the control group.Both groups were treated for 6 weeks.The clinical efficacy,score of TCM syndromes,gastric mucosa pathological score and gastric mucosal inflammation indexes [interleukin-11 (IL-11),interleukin-12 (IL-12),C reactive protein (CRP) and tumor necrosis factor-α (TNF-α)] and gastric mucosal immune function indexes (CD4 +,CD8 + and CD4 +/CD8 +).Results The total effective rate of the treatment group was 94.29％,which was significantly higher than 75.76％ of the control group (P ＜0.05).After treatment of 6 weeks,the scores of TCM syndromes in both groups were significantly lower than those before treatment (P ＜ 0.05),and the scores of main TCM symptom such as epigastric pain,abdominal nausea after eating,loss of appetite and score of minor TCM symptom such as nausea and vomiting and total score in the treatment group were significantly lower than those in the control group (P ＜ 0.05).After 6 weeks of treatment,the gastric mucosa pathological score in both groups was significantly lower than that before treatment (P ＜ 0.05),and the score of the treatment group was significantly lower than that of the control group (P ＜ 0.05).After treatment of 6 weeks,the gastric mucosal inflammation indexes and gastric mucosal immune function indexes in both groups were significantly lower than those before treatment (P ＜ 0.05),and these indexes in the treatment group were significantly lower than those in the control group (P ＜ 0.05).Conclusion Stomach-tonifying decoction combined with western medicine is effective in treating patients with yin deficiency syndrome of stomach of chronic atrophic gastritis,which can significantly improve the clinical symptoms and reduce the degree of inflammatory reactions of gastric mucosa,so it is worthy of clinical application.
