Clinical efficacy and safety of ginkgo biloba extract combined with clopidogrel in the treatment of patients with ischemic stroke
10.7619/jcmp.201807009
- VernacularTitle:银杏叶提取物联合氯吡格雷治疗缺血性脑卒中的临床疗效与安全性
- Author:
Lianjun ZHANG
1
;
Ming MO
;
Dongmei XU
Author Information
1. 江苏省荣军医院药剂科
- Keywords:
ginkgo biloba extract;
ischemic stroke;
clopidogrel;
clinical efficacy;
safety
- From:
Journal of Clinical Medicine in Practice
2018;22(7):35-37,41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of ginkgo biloba extract combined with clopidogrel in the treatment of patients with ischemic stroke.Methods Totally 80 patients with ischemic stroke were randomly divided into observation group and control group,40 cases in each group.Both groups received routine therapies such as lipid-lowering,antihypertensive and microcirculation improvement.The control group received clopidogrel 75 mg for once per day.The observation group received 2 tablets of ginkgo tablet,three times per day.Clinical efficacy,blood rheology indexes,blood pressure,NIHSS score,ADL score,coagulation indexes,fibrinolysis indexes and adverse reactions were compared between two groups.Results The total effective rate and the scores of NIHSS and ADL in the observation group were significantly better than those in the control group (P ＜ 0.05).The blood rheology indexes,blood pressure,coagulation and fibrinolysis indexes of the two groups significantly improved after treatment (P ＜ 0.05),and the indexes in the observation group improved more significantly when compared with control group (P ＜ 0.05).There was no significant difference in the incidence rate of adverse reactions between two groups (P ＞ 0.05).Conclusion Ginkgo biloba extract combined with clopidogrel is effective in the treatment of patients with ischemic stroke,and it has a good synergistic effect.
