Effect of berberine on the expression of PGC-1α/GLUT4 in mice with insulin resistance
- VernacularTitle:小檗碱对胰岛素抵抗模型小鼠过氧化物酶体增殖物激活受体γ辅激活因子1α/骨骼肌葡萄糖转运蛋白4表达的影响
- Author:
Shiwei WAN
1
;
Mei YU
;
Ke ZHANG
;
Shiyu HAN
;
Yizhi SHANG
;
Penghua FANG
;
Zhenwen ZHANG
Author Information
- Keywords: berberine; insulin resistance; PGC-1α; GLUT4
- From: Journal of Clinical Medicine in Practice 2018;22(7):7-10
- CountryChina
- Language:Chinese
- Abstract: Objective To observe the effect of berberine on the expression of GLUT4 and PGC-1α in mice with insulin resistance,and to explore the molecular mechanism of berberine in improving insulin resistance.Methods Mice models with insulin resistance were established,and berberine was used by intragastric administration to detect blood glucose,insulin and insulin sensitivity.RT-PCR was used to detect the expression level of GLUT4 and mRNA of PGC-1α in skeletal muscle.Results Berberine significantly reduced blood sugar,increased insulin sensitivity,and promoted the expression of GLUT4 and PGC-1α in skeletal muscle.Conclusion Berberine can improve the expression of PGC-lo,promote the expression of GLUT4 and improve insulin resistance.
