Clinical effect of aspirin before pregnancy combined with low molecular heparin during pregnancy on treatment of patients with recurrent spontaneous abortion caused by prethrombotic state
10.7619/jcmp.201803033
- VernacularTitle:孕前阿司匹林联合孕期小剂量低分子肝素钠治疗血栓前状态导致复发性流产的临床效果
- Author:
Minyan YANG
1
;
Guanyou HUANG
;
Shuyun ZHAO
;
Jun WANG
Author Information
1. 贵州医科大学附属医院
- Keywords:
prethrombotic state;
recurrent spontaneous abortion;
aspirin;
low molecular heparin
- From:
Journal of Clinical Medicine in Practice
2018;22(3):115-116,119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of aspirin before pregnancy combined with low molecular heparin during pregnancy on treatment of patients with recurrent spontaneous abortion caused by prethrombotic state.Methods A total 60 patients with recurrent spontaneous abortion were randomly divided into treatment group and control group,30 cases in each group.The treatment group was treated with small dose of aspirin before pregnancy and low dosage molecular heparin during pregnancy,while the control group was treated with low dosage molecular heparin during pregnancy.Pregnancy outcome was compared between two groups.Results The partus maturus rate of treatment group was significantly higher than control group (P ＜ 0.05),and abortion rate was significantly lower than control group (P ＜ 0.05).Conclusion Aspirin before pregnancy combined with low molecular heparin during pregnancy is effective in treatment of patients with recurrent spontaneous abortion caused by prethrombotic state,which can increase partus maturus rate and reduce abortion rate.
