Influence of hyperbaric oxygen therapy for middle aged and elderly patients with acute cerebral infarction and its effect on M-CSF, ox-LDL and sICAM-1
10.7619/jcmp.201803002
- VernacularTitle:高压氧治疗中老年急性脑梗死的临床疗效及对患者巨噬细胞集落刺激因子、氧化修饰低密度脂蛋白、可溶性细胞黏附因子-1的影响
- Author:
Hong ZHOU
1
;
Shuping YE
;
Lijing WANG
Author Information
1. 北京丰台医院神经内科
- Keywords:
hyperbaric oxygen;
acute cerebral infarction;
M-CSF;
ox-LDL;
sICAM-1
- From:
Journal of Clinical Medicine in Practice
2018;22(3):9-11,15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical efficacy of hyperbaric oxygen therapy in the treatment of middle-aged and elderly patients with acute cerebral infarction and their effects on M-CSF,ox-LDL and sICAM-1.Methods A total of 100 elderly patients with acute cerebral infarction who were treated in our hospital were divided into control group and study group according to the random number table method,with 50 cases in each group.The patients in the control group were treated with conventional therapy,and the patients in the study group were treated with hyperbaric oxygen therapy.The levels of serum markers,nerve defect function and cerebral cerebral blood flow (CBF),cerebral blood volume (CBV) were observed and compared between the two groups before and after treatment.Results After treatment,the levels of M-CSF,ox-LDL and sICAM-1 in the two groups were lower than treatment before,and study group was lower than the control group (P ＜ 0.05);The total clinical outcomes was higher in the study group than that in the control group (P ＜ 0.05).After treatment,the CBF and CBV levels of the two groups were higher than treatment before,and the study group was higher than the control group(P ＜0.05).Conclusion Hyperbaric oxygen therapy in the treatment of the elderly with acute cerebral infarction can effectively reduce the expression of M-CSF,ox-LDL,sICAM-1,reduce cerebral vascular injury,inhibit the formation of thrombosis,improve the function of nerve deficit,relieve the insufficient of oxygen supply,so it is worthy of clinical promotion.
