Effect observation of pemetrexed combined with platinum on the treatment of patients with advanced non-squamous non-small cell lung cancer
10.7619/jcmp.201801020
- VernacularTitle:培美曲塞联合铂类一线药物治疗晚期非鳞型非小细胞癌的疗效观察
- Author:
Jian YANG
1
;
Shixi CHEN
;
Weidong XU
Author Information
1. 江苏省淮安市金湖县中医院
- Keywords:
advanced non-squamous non-small cell lung cancer;
pemetrexed;
efficacy;
safety
- From:
Journal of Clinical Medicine in Practice
2018;22(1):65-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and safety of pemetrexed combined with platinum in the treatment of patients with advanced non-squamous non-small cell lung cancer.Methods A total of 74 patients with advanced non-squamous non-small cell lung cancer were collected,35 cases in the control group were treated with cisplatin,and 39 cases in observation group was treated with pemetrexed combined with cisplatin.After two cycles of treatment,therapeutic effect,toxic reaction and complications were compared between two groups.Results The partial remission rate of the observation group was 38.5％,which was significantly higher than 20.0％ of the control group,and the rate of progress was 7.7％,which was significantly lower than 17.1％ of the control group.The adverse reactions and complications such as nausea and vomiting,abdominal pain,diarrhea,alopecia,neurotoxicity,thrombocytopenia,leukocyte reduction and liver function damage showed no significant differences between two groups.Conclusion Pemetrexed combined with cisplatin can significantly improve the clinical efficacy of chemotherapy in patients with non-squamous cell lung cancer without increasing the adverse effects of chemotherapy.
