Expression and significance of Toll-like receptor in bone marrow mononuclear cells of patients with multiple myeloma
10.7619/jcmp.201801019
- VernacularTitle:Toll样受体在多发性骨髓瘤患者骨髓单个核细胞中的表达水平及意义
- Author:
Ying CHEN
1
;
Jinxia HAO
;
Jing ZHAO
;
Dengzhe LI
;
Mei ZHANG
Author Information
1. 西安交通大学第一附属医院血液内科
- Keywords:
Toll-like receptors;
multiple myeloma;
bone marrow mononuclear cells;
clinical stage;
M protein
- From:
Journal of Clinical Medicine in Practice
2018;22(1):61-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Toll-like receptor (TLR) in bone marrow mononuclear cells (BMMCs) of patients with multiple myeloma (MM) and its significance.Methods Totally 30 patients with MM were selected as observation group,and 10 patients with proliferative anemia were selected as control group.Patients in the observation group were treated with bortezomib combined with dexamethasone chemotherapy.The expression level of TLR in BMMCs was detected by real-time fluorescence quantitative method in both groups.The relationship between TLR and the clinical stages of MM was analyzed.Results The relative expression levels of TLR-4 and TLR-9 in BMMCs in the observation group were significantly higher than those in the control group (P ＜ 0.05).The expression levels of TLR-4 and TLR-9 in patients with different stages of MM showed significant differences (P ＜ 0.05).TLR-4 was positively correlated with M protein and β2-MG (r =0.673,0.466,P =0.023,0.041),and TLR-9 was also positively correlated with M protein and β2-MG (r =0.547,0.424,P =0.031,0.048).After treatment,the relative expression levels of TLR-4 and TLR-9 in BMMCs in patients with MM decreased significantly (P ＜ 0.05).Conclusion The expression levels of TLR-4 and TLR-9 are obviously higher in patients with MM,which is related to the clinical stage,M protein and β2-MG.
