Clinical analysis of immune status in patients with severe sepsis shock
10.7619/jcmp.201801002
- VernacularTitle:重症脓毒症休克患者免疫状况的临床分析
- Author:
Xiangzhong MENG
1
;
Xiaoning ZHANG
;
Yu ZHU
;
Wenxu ZHANG
Author Information
1. 解放军第二五四医院重症医学科
- Keywords:
sepsis shock;
immunity disorder;
immunoglobulin;
NK cells
- From:
Journal of Clinical Medicine in Practice
2018;22(1):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical immune status of patients with severe sepsis shock.Methods A total of 45 patients with sepsis in general ward and 45 severe sepsis shock patients treated in our hospital were selected for the study,and were as control group and observation group,respectively.The T lymphocyte,B lymphocyte and CD3+ CD4+,CD3+ CD8+,NK cells,immunoglobulin IgG,IgA,IgM levels,complement C3,C4 were detected in the two groups.The cellular immune function,humoral immune function and inflammatory reactions were compared between the two groups.Results The T lymphocyte count in the observation group and the control group were (60.0 ±16.2)％ and (77.2 ± 18.5)％,respectively,and The B lymphocyte count were (25.1 ± 10.2)％,and (14.3 ±6.9)％,respectively.The CD3+ CD8+ in the observation group was significantly lower,and CD4+/CD8+ was significantly higher than that in the control group (P ＜ 0.05).The percentage of NK cells and CD3 + CD8 + in the two groups showed no significant difference (P ＞ 0.05).The concentration of C4 and IgM in the observation group were significantly lower than that in the control group (P ＜ 0.05),and there was no significant difference between the two groups in C3,IgG and IgA (P ＞ 0.05).The WBC count,procalcitonin and C reactive protein in the observation group were significantly higher than that in the control group (P ＜ 0.05).Conclusion Severe septic shock patients have severe immune disorder.
