Analysis of predisposing factors of postoperative complications of 706 patients and the differential expression of key genes in early and advanced stages of esophageal cancer
10.7619/jcmp.201719026
- VernacularTitle:706例食管癌术后并发症诱因及早晚期食管癌关键基因差异性表达研究
- Author:
Yizhi ZHU
1
;
Ye XU
;
Xueyan WANG
;
Lingxiang LIU
Author Information
1. 南京医科大学
- Keywords:
esophageal cancer;
postoperative complications;
predisposing factors;
tumor staging;
mRNA;
DNA methylation;
gene mutation;
difference
- From:
Journal of Clinical Medicine in Practice
2017;21(19):91-94,98
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the predisposing factors of postoperative complications of esophageal cancer,and analyze the different genetic expression of mRNA,DNA methylation and mutations with different esophageal cancer staging.Methods A total of 706 patients with esophageal cancer from the First Affiliated Hospital of Nanjing Medical University and Jiangsu People's Hospital from 2010 to 2013 and 2015 to 2016 were involved in this study.Data of genetic information from 107 patients with esophageal cancer were obtained from the Cancer Genome Atlas (TCGA) database.Results The analysis showed that age was correlated with SEP (P =0.011),and pTNM staging was correlated with the occurrence of AF (P =0.010) and CL (P =0.030).The postoperative nutritional pattern was also significantly associated with the occurrence of AF (P =0.041).There was a significant difference in the expression of EPHA3 mRNA in patients with esophageal cancer in different TNM stage (P =0.006),DNA methylation level of NOTCH1 (P =0.027),and mutations genes such as ZNF750 (P =0.037) and MALAT1 (P =0.044).Conclusion Postoperative complications of esophageal cancer could be associated with patients'age,TNM staging and postoperative nutritional patterns.The expression of EPHA 3 mRNA and the DNA methylation of NOTCH 1 show significant difference in different TNM stages of esophageal cancer,and both of them have higher expression in advanced patients.Mutation of ZNF750 and MALAT1 are negatively correlated with the staging of esophageal carcinoma.
