Effect of gonadotropin releasing hormone analogues after laparoscopic surgery on treatment of patients with endometriosis
10.7619/jcmp.201719018
- VernacularTitle:子宫内膜异位症患者腹腔镜术后应用促性腺激素释放激素类似物的效果观察
- Author:
Feng ZHANG
1
;
Shaojie ZHAO
;
Jinmei WANG
Author Information
1. 江苏省无锡市妇幼保健院妇产科
- Keywords:
endometriosis;
laparoscopy;
gonadotropin releasing hormone antagonists;
efficacy
- From:
Journal of Clinical Medicine in Practice
2017;21(19):63-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of gonadotropin-releasing hormone antagonist (GnRHa) and gestrinone after laparoscopic surgery in patients with endometriosis.Methods Ninety patients with endometriosis who underwent laparoscopic surgery in our hospital were selected as the subjects.The patients in the control group were treated with gestrinone,while the observation group received GnRHa treatment.Treatment efficacy after treatment,reproductive hormone levels,adverse reactions and recurrence condition were compared.Results The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant (93.3％ vs.71.1％,P ＜ 0.05).The levels of serum reproductive hormone (FSH,LH,E2,PRL) in the two groups were significantly lower than treatment before (P ＜ 0.05),and the levels of FSH,LH in the observation group were significantly lower than the control group (P ＜ 0.05).The incidence of adverse reactions showed no significant difference (P ＞ 0.05).The patients in the two groups were followed up for 1 to 2 years.Among them,9 cases had recurrence in the control group and 3 cases in the observation group,and significant difference was seen between the two groups (P ＜0.05).Conclusion GnRHa therapy is more safe,and effective and has lower relapse rate.
