Effects of aspirin combined with clopidogrel on Hcy and hs-CRP in patients with cerebral infarction and analysis prognosis
10.7619/jcmp.201719011
- VernacularTitle:阿司匹林联合氯吡格雷对脑梗死患者同型半胱氨酸、超敏C反应蛋白的影响及预后分析
- Author:
Zhiqiang FENG
1
;
Yunnan LU
;
Hong XU
;
Tao MA
;
Yumin LIU
;
Shuangshuang WU
;
Ye HUA
Author Information
1. 南京医科大学附属无锡市第二人民医院神经内科
- Keywords:
cerebral infarction;
aspirin;
clopidogrel;
prognosis
- From:
Journal of Clinical Medicine in Practice
2017;21(19):38-40,43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effects of aspirin combined with clopidogrel on Hcy and hs-CRP in patients with cerebral infarction.Methods A total of 69 patients with cerebral infarction in our hospital were divided into two groups,patients in observation group with 39 cases were treated with aspirin combined with clopidogrel,and control group with 29 cases treated with aspirin.The therapeutic effects of two groups,the changes of serum Hcy,hs-CRP and NIHSS scores before and after treatment were observed.Results Hcy and hs-CRP levels were significantly decreased in the observation group and the control group after seven days of treatment.However,the observation group was significantly lower.After treatment,NIHSS score decreased in both groups,however,there was no significant difference in NIHSS in two groups.The ESS and ADL score were significantly improved,and observation group was better than the control group after 21 days of treatment(P ＜0.05).Conclusion Aspirin combined with clopidogrel can significantly reduce serum Hcy and hsCRP levels,and improve the prognosis in patients with cerebral infarction.
