Correlation study between ratio of aldosterone to renin and heart rate variability, QT interval in patients with essential hypertension
10.7619/jcmp.201719002
- VernacularTitle:原发性高血压患者醛固酮/肾素比值与心率变异性和QT间期的关系研究
- Author:
Min DENG
1
;
Daxin WANG
;
Yong XIE
;
Shenghu HE
;
Xiujue ZHANG
;
Qingyong ZHU
;
Yong CHENG
;
Rixin XU
Author Information
1. 扬州大学临床医学院苏北人民医院心内科
- Keywords:
essential hypertension;
aldosterone;
heart rate variability;
QT interval
- From:
Journal of Clinical Medicine in Practice
2017;21(19):6-9,13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between aldosterone/renin ratio (ARR) and heart rate variability (HRV),QT interval in patients with essential hypertension.Methods A total of 179 people were divided into two groups according to median number of ARR,and 24 h Holter,24 h ambulatory blood pressure,ECG,serum potassium,serum sodium were monitored,then HRV and QT interval index were compared between the two groups.Results There were significant differences between the two groups in SDNN,SDNN index,SDANN index,RMSSD,QTc,blood potassium,sodium (P ＜ 0.05),while gender,age,diabetes,smoking,BMI,average heart rate,heart rate standard deviation showed no significant difference.At the same time,correction factors showed that ARR was still negatively correlated with SDNN,SDNN Index,SDANN Index,RMSSD,serum potassium (r =-0.444,-0.677,-0.381,-0.623,-0.432,P ＜ 0.05),andwaspositivelycorrelated with QTc,serum sodium (r =0.391,0.379,P ＜ 0.05).Multivariate logistic regression analysis showed that SDNN,SDNN Index,SDANN Index were the independent factors related to ARR (P ＜0.05).Conclusion High aldosterone is closely related to heart rate variability reduction.
