Clinical effect of clomiphene combined with human chorionic gonadotropin on ovulation induction in infertility patients with polycystic ovary syndrome
- VernacularTitle:克罗米芬联合人绒毛膜促性腺激素对多囊卵巢综合征不孕患者促排卵的临床效果观察
- Author:
Maimaiti · MAYILA
1
;
Yiming · ZULIPIYA
Author Information
- Keywords: polycystic ovary syndrome; infertility; clomiphene; human chorionic gonadotropin
- From: Journal of Clinical Medicine in Practice 2017;21(17):72-75
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the clinical effect of clomiphene combined with human chorionic gonadotropin (HCG) on ovulation induction in infertility patients with polycystic ovary syndrome (PCOS).Methods A total of 62 infertile women caused by PCOS were randomly divided into 2 groups,with 31 cases per group.The control group was treated with clomiphene,while the observation group was treated with HCG treatment based on the control group.Levels of serum reproductive endocrine hormone was detected,endometrial receptivity was assessed,and ovulation and pregnancy outcomes were compared.Results Compared with treatment before,T and LH levels of two groups were lower (P ＜ 0.05),FSH and E2 levels had no changes (P ＞ 0.05),levels of endometrial spiral artery PI and RI increased (P ＜ 0.01),endometrial thickness increased(P ＜ 0.01).Compared with the control group,levels of LH in observation group were lower (P ＜ 0.05),endometrial spiral artery PI,RI were higher (P ＜ 0.01),endometrial thickness were higher(P ＜ 0.01),the rate of ovulation and follicular growth rate and clinical pregnancy rate were higher (P ＜ 0.05),early abortion rate was lower (P ＜ 0.05),and the total clinical efficiency was higher(P ＜ 0.05).Conclusion The efficacy of clomiphene combined with HCG in the treatment of infertility caused by polycystic ovary syndrome is better than single treatment of clomiphene.
