Effect of yin-tonifying and fire-removing prescription on IL-10 and IL-18 in systemic lupus erythematosus patients with syndrome of internal heat due to yin deficiency
- VernacularTitle:滋阴降火法对阴虚内热证系统性红斑狼疮患者细胞因子IL-10、IL-18的影响
- Author:
Xiaohui XIE
1
;
Chenguang DU
;
Peijie DING
;
Dingjie XU
;
Jiaojiao ZHAO
;
Yushan DONG
Author Information
- Keywords: yin-tonifying and fire-removing prescription; syndrome of internal heat due to yin deficiency; systemic lupus erythematosus; IL-10; IL-18
- From: Journal of Clinical Medicine in Practice 2017;21(17):61-63
- CountryChina
- Language:Chinese
- Abstract: Objective To observe the effect of yin-tonifying and fire-removing prescription on IL-10 and IL-18 in systemic lupus erythematosus patients with syndrome of internal heat due to yin deficiency.Methods A total of 86 systemic lupus erythematosus patients with syndrome of internal heat due to yin deficiency were enrolled and randomly divided into control group and research group,43 cases in each group.The control group was treated with conventional western medicine,while research group was treated with yin-tonifying and fire-removing prescription on basis of control group.The TCM symptom score,serum IL-10 and IL-18 levels and the incidence rate of adverse reactions were compared between the two groups.The clinical efficacy of the two groups was evaluated.Results Mter treatment,the levels of IL-10 and IL-18 in both group decreased significantly,and the levels in research group were significantly lower than control group (P ＜ 0.05).The total effective rate was 95.35％ in research group,which was significantly higher than 69.77％ in the control group (P ＜ 0.05).The incidence rate of adverse reactions was 6.98％ in the research group,whichwas similar to 9.30％ in the control group (P ＞ 0.05).Conclusion For systemic lupus erythematosus patients with syndrome of internal heat due to yin deficiency,yin-tonifying and fire-removing prescription can significantly improve the clinical efficacy,alleviate clinical symptoms,and will not increase the incidence rate of adverse reactions.
