Effect of positive reduction of blood pressure in acute period on reperfusion of patients with acute ischemic stroke by intravenous thrombolysis
- VernacularTitle:急性缺血性卒中静脉溶栓患者急性期积极降压对再灌注的影响分析
- Author:
Hao MENG
1
;
Linjun YANG
;
Yan PU
Author Information
- Keywords: acute ischemic stroke; intravenous thrombolysis; positive hypertension repressing; reperfusion
- From: Journal of Clinical Medicine in Practice 2017;21(17):31-34
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the effect of positive reduction of blood pressure on reperfusion of patients with acute ischemic stroke by intravenous thrombolysis.Methods A total of 96 acute ischemic stroke patients with intravenous thrombolysis of rt-PA and systolic blood pressure 150 to 185 mmHg selected and randomly divided into observation group and control group,48 cases in each group.The patients in the observation group received positive reduction of blood pressure in the acute phase,which indicated the systolic blood pressure was controlled at 140 to 150 mmHg and maintained at least 72 h in the beginning of 60 minutes.Patients in the control group received standard blood pressure according to the guidelines,which indicated systolic blood pressure control below 180 mmHg.The patients in both groups were given multi mode MRI examination before and 24 h,48 h and 72 h after intravenous thrombolysis.The levels of blood pressure,National Institute of Health stroke scale (NIHSS),blood flow reperfusion and recanalization of the two groups were recorded.The two groups were followed up for a period of three months.The survival status and the modified Rankin scale scores of the two groups were observed.Results Compared with the control group,the systolic blood pressure of 24,48 and 72 h in the observation group were lower than that of the control group,but there was no significant difference in diastolic blood pressure and NIHSS scores in the two groups (P ＞ 0.05).There were no significant differences between the two groups in the rate of spontaneous intracerebral hemorrhage,survival rate,modified Rankin score (0 ～ 2),blood flow reperfusion rate and vascular recanalization rate (P ＞ 0.05).Conclusion Acute venous thrombosis in the acute phase of reperfusion for acute ischemic stroke patients has no adverse effects on reperfusion and no increase of morbidity and death risk of patients,and intravenous thrombolysis to avoid systolic pressure rise can improve the prognosis of patients.
