Study on inhibition of colorectal cancer cell proliferation via down-regulation of SIX1 expression of histone deacetylase 5
10.7619/jcmp.201717001
- VernacularTitle:组蛋白去乙酰化酶5下调SIX1的表达以抑制结直肠癌细胞增殖的研究
- Author:
Jiawei WANG
1
;
Andong XU
;
Yunxiang ZHU
Author Information
1. 扬州大学附属医院普外科
- Keywords:
colorectal cancer;
histone deacetylase;
SIX1;
proliferation
- From:
Journal of Clinical Medicine in Practice
2017;21(17):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate expression of histone deacetylase 5 (HDAC5) in normal and colorectal cancer (CRC) tissues and its mechanism.Methods Immunohistochemistry was used to detect the expression of HDAC5 in CRC tissues.The relationship between HDAC5 expression content and survival prognosis was analyzed.Proliferation,immigration and apoptosis changes were observed after knockdown of HDAC5.Results Positive expression of HDAC5 in tumor tissue was related with poor prognosis of CRC patients,and HDAC5 could inhibit the LS174T cell proliferation by regulating the SIX1 expression.Conclusion Our results reveal that HDAC5 expression is variant in CRC tissues,and it is correlated with prognosis of colorectal cancer,and can affect cell proliferation by regulating the SIX1 expression.
