Effect of bicalutamide combined with goserelin on the expressions of Raptor protein and SMYD3 in tumor tissue of patients with advanced prostate cancer
10.7619/jcmp.201715014
- VernacularTitle:比卡鲁胺联合戈舍瑞林对晚期前列腺癌患者肿瘤组织中Raptor蛋白及SMYD3表达的影响
- Author:
Chuan GUO
1
;
Ge YANG
;
Yongchang PU
;
Linhai LIU
;
Yang ZHANG
;
Yong WANG
Author Information
1. 四川省内江市第二人民医院泌尿外科
- Keywords:
bicalutamide;
goserelin;
prostate cancer;
Raptor protein;
prostate specific antigen
- From:
Journal of Clinical Medicine in Practice
2017;21(15):53-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of bicalutamide combined with goserelin on the expressions of Raptor and SMYD3 in tumor tissue of patients with advanced prostate cancer.Methods A total of 58 patients with advanced prostate cancer were randomly divided into control group and observation group, 29 cases in each group.The control group was treated with bicalutamide and continuous administration of goserelin, while the observation group was treated with the same dose of bicalutamide and intermittent administration of goserelin.The pain relief rate, quality of life and the incidence rate of adverse reactions were analyzed.Raptor protein and SMYD3 expressions were detected in both groups.Results The pain relief rate was 82.76% in the observation group, which was significantly higher than 37.93% in the control group (P=0.000).After treatment, the prostate specific antigen (PSA) decreased significantly in both groups (P=0.000).After treatment, the Raptor staining intensity and SMYD3 expression rate were significantly lower in the observation group than the control group (P=0.000).The score of SF-36 in the observation group was significantly higher than that in the control group, and the incidence rate of adverse reactions in the observation group was significantly lower than that in the control group (P=0.000).Conclusion Bicalutamide combined with goserelin can effectively control Raptor protein and SMYD3 expression in patients withadvanced prostate cancer, and the intermittent administration of drugs has a better therapeutic effect and higher safety.
