Effects of calcium disodium and water-soluble vitamins on serum T lymphocytes and oxidative stress in patients with occupational lead poisoning
10.7619/jcmp.201715009
- VernacularTitle:依地酸二钠钙联合水溶性维生素对职业性铅中毒患者血清T淋巴细胞及氧化应激的影响
- Author:
Li ZHANG
1
;
Hengdong ZHANG
Author Information
1. 江苏省疾病预防控制中心职业病防治所
- Keywords:
calcium disodium;
water-soluble vitamin;
occupational lead poisoning;
serum T lymphocytes;
oxidative stress
- From:
Journal of Clinical Medicine in Practice
2017;21(15):34-36,40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of calcium disodium and water-soluble vitamins on serum T lymphocytes and oxidative stress in patients with occupational lead poisoning.Methods A total of 140 occupational lead poisoning patients in our hospital were randomly divided into control group with 70 cases treated by water soluble vitamins and study group with 70 cases treated with calcium disodium on the basis of the control group.The CD3+, CD4+ and CD8+ activity of T lymphocytes subsets were compared, superoxide dismutase (SOD) and malondialdehyde (MDA) levels, and lead concentration in urine and blood were determined.Meanwhile, the clinical outcomes and adverse reactions of two groups were compared.Results The effective rate of the control group was significantly lower than that of the study group (75.61% vs.92.86%, P<0.05).Compared with the control group, the patients in the study group had lower CD4+ activity, higher CD8+ activity, lower CD4+/CD8+ activity, higher levels of SOD and MDA, and lower lead concentrations in urine and blood, and the differences were statistically significant(P<0.05).Conclusion Calcium disodium and water-soluble vitamins can effectively improve the level of serum T lymphocytes and oxidative stress, decrease the concentration of lead in urine and blood.
