Relationship between cytotoxic associated protein A, cytotoxic associated protein E, vacuolating cytotoxin A genotypes of Helicobacter pylori and upper digestive tract diseases
10.7619/jcmp.201713010
- VernacularTitle:幽门螺杆菌细胞毒素相关蛋白A、细胞毒素相关蛋白E、细胞空泡毒素A基因型与上消化道疾病的关系
- Author:
Minren JIANG
1
;
Ying HUANG
;
Jiahong SONG
;
Yuanyuan YE
Author Information
1. 同济大学附属第十人民医院 消化内科
- Keywords:
Helicobacter pylori;
cytotoxic associated protein A;
cytotoxic associated protein E;
vacuolating cytotoxin A;
genotypes;
upper gastrointestinal diseases
- From:
Journal of Clinical Medicine in Practice
2017;21(13):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between cytotoxin associated protein A (cagA), cytotoxin associated protein E(cage), vacuolating cytotoxin A (vacA) genotypes of Helicobacter pylori (Hp) and the upper digestive tract diseases. Methods A total of 112 patients with upper gastrointestinal diseases were selected. The cagA, cagE, vacA genotypes of Hp strains in gastric mucosa of the patients were detected and analyzed. Results All Hp strains in the gastric mucosa samples of patients were found with both cagA gene and cagE gene expression, and the positive rate was 100%. The positive rates of vacA s1/m2 genotype in the patients were the highest with 54.1% and 60.5% respectively, followed by the vacA s1/mlb genotype and vacA s1/m- phenotypes, and the positive rates were from 13.2% to 21.1%. The differences of positive rates of each genotypes in Hp genes between the patients with peptic ulcer and chronic gastritis were not significant (P>0.05). Conclusion Hp strains in gastric mucosa patients with upper gastrointestinal diseases show the advantage expressions of cagA, cagE, vacA s1/m2 subtypes, which refers that such virulence phenotypes may play important roles in initiation and promotion process of upper gastrointestinal diseases by Hp, but the correlation with the type of upper digestive tract diseases is not proved.
