Changes and significance of serum tumor markers before and after chemotherapy in patients with advanced non-small cell lung cancer
10.7619/jcmp.201713007
- VernacularTitle:晚期非小细胞肺癌化疗
- Author:
Ming LI
1
;
Guangyuan HU
;
Qi MEI
;
Hong LIAO
Author Information
1. 湖北省武汉市肺科医院 肿瘤科
- Keywords:
advanced non-small cell lung cancer;
chemotherapy;
anterior gradient 2;
soluble interleukin-2 receptor;
serum thymidine kinase 1
- From:
Journal of Clinical Medicine in Practice
2017;21(13):26-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the changes of serum tumor markers before and after chemotherapy in patients with advanced non-small cell lung cancer.Methods Fifty-two patients with advanced non-small cell lung cancer by chemotherapy were selected as observation group,and forty-five healthy controls were selected as control group.Peripheral blood anterior gradient precursor protein 2(AGR2),soluble interleukin-2 receptor(SIL-2R)and serum thymidine kinase 1(TK1)levels were detected before and after treatment in both groups.Results The curative effects of the observation group were 0 case of complete remission(grade 1),16 cases of partial remission(grade 2),19 cases of stability(grade 3)and 17 cases of progression(grade 4).After treatment,the levels of AGR2,SIL-2Rand TK1 decreased significantly in observation group(P<0.05).Correlation analysis showed that after two cycles of treatment,the levels of AGR2,SIL-2R and TK1 were positively correlated with the therapeutic effect grade(P<0.05).Conclusion AGR2,SIL-2R and TK1 reduce significantly after chemotherapy in patients with advanced non-small cell lung cancer,and its decreasing level is correlated with chemotherapy effect.
