Effect of tiotropium bromide combined with inhalation therapy of seretide on pulmonary function and prognosis of patients with moderate and severe chronic obstructive pulmonary disease
10.7619/jcmp.201713006
- VernacularTitle:噻托溴铵联合舒利迭雾化吸入治疗对中重度慢性阻塞性肺疾病患者肺功能状况及预后的影响
- Author:
Liping SONG
1
;
Pingchao XIANG
Author Information
1. 北京大学首钢医院 呼吸内科
- Keywords:
moderate to severe chronic obstructive pulmonary disease;
tiotropium bromide;
inhalation therapy;
pulmonary function;
prognosis
- From:
Journal of Clinical Medicine in Practice
2017;21(13):22-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of tiotropium combined with seretide inhalation therapy on pulmonary function and prognosis of patients with moderate and severe chronic obstructive pulmonary disease(COPD).Methods A total of 91 patients with moderate and severe COPD were divided into observation group(n=48)and control group(n=43).The control group was only given seretide inhalation,while the observation group was given additional tiotropium bromide inhalation therapy on the basis of the control group.The pulmonary function and prognosis before and after treatment were compared between the two groups.Results After treatment,the levels of FEV1,FVC,FEV1/FVC/％and FEV1％pre in the observation group were significantly higher than those in the control group(P<0.05).In the observation group,the p(O2),p(CO2)after treatment were significantly better than the control group(P<0.05).The levels of hs-CRP,IL-6 and PCT were significantly lower in the observation group than the control group(P<0.05).The dyspnea score,CAT score and SGRQ score of the observation group after treatment were significantly lower than those of the control group,and the 6 min walking test was significantly higher than the control group(P<0.05).Conclusion For patients with moderate and severe COPD,tiotropium combined with seretide inhalation therapy can significantly improve their pulmonary functions and arterial blood gas status,alleviate inflammatory response,so it is worthy of popularization.
