Association between CYP17A1 gene polymorphism and essential hypertension
10.7619/jcmp.201713003
- VernacularTitle:CYP17A1基因多态性与原发性高血压的相关性研究
- Author:
Xiaoyan DIAO
1
;
Yan HE
Author Information
1. 贵州医科大学心血管科
- Keywords:
essential hypertension;
CYP17A1;
gene polymorphism;
acquired factors
- From:
Journal of Clinical Medicine in Practice
2017;21(13):8-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between rs11191548 gene locus polymorphism in CYP17A1 gene and essential hypertension.Methods A total of 143 patients with essential hypertension and 199 healthy subjects were selected.TaqMan probe was used to analyze the genotype of rs11191548 gene locus in CYP17A1 gene and their correlation was analyzed.Stepwise Logistic regression analysis was used to analyze the influence of acquired factors on hypertension.Results There was significant difference in genotype distribution and allele frequency distribution between the two groups(P<0.05).TT and CT genotype had higher risk for diseases compared with CC genotype,the CC genotype of the risk of hypertension was 0.370 times with the TT genotype,and individuals carrying the T allele were 1.776 times the risk of hypertension with C allele.Fasting blood glucose,triglycerides,and older people were more likely to have a higher risk of hypertension.Conclusion The rs11191548 polymorphism of CYP17A1 gene may be associated with the pathogenesis of essential hypertension,and the individuals with TT genotype and T allele may be at increased risk of developing hypertension.Acquired factors have a significant impact on the incidence of hypertension.
