Effect of preoperative application of leuprorelin acetate on hormone levels,menstrual and uterine fibroids recurrence in patients with laparoscopic myomectomy
10.7619/jcmp.201711031
- VernacularTitle:术前应用醋酸亮丙瑞林对腹腔镜下子宫肌瘤剔除患者激素水平、月经及子宫肌瘤复发的影响
- Author:
Ke XIE
1
;
Binbin YE
Author Information
1. 陕西省安康市人民医院 妇产科
- Keywords:
leuprorelin acetate;
laparoscope;
myomectomy;
hormone
- From:
Journal of Clinical Medicine in Practice
2017;21(11):104-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of preoperative application of leuprolide acetate on hormone levels,menstrual and uterine fibroids recurrence in patients with laparoscopic myomectomy.Methods A total of 100 patients with hysteromyoma were randomly divided into experimental group (n=50) and control group (n=50).The control group was treated with laparoscopic myomectomy,while the experimental group was treated with leuprorelin acetate before laparoscopic myomectomy.The levels of serum hormones,menstruation,fibroid volume and recurrence rate of uterine fibroids were observed.Results In the experimental group,after use of leuprolide acetate,the luteinizing hormone,follicle stimulating hormone and serum estradiol were significantly lower than those before treatment,and menstrual blood volume,uterine volume,leiomyoma volume were significantly less than those before treatment (P<0.05).Compared with the control group,the amount of bleeding in operation and pelvic drainage were significantly lower,and ambulation time,hospitalization time were significantly shorter in experimental group (P<0.05).Conclusion Before the laparoscopic myomectomy,the clinical efficacy and safety of leuprolide acetate is great,which can reduce the serum hormone level,improve the volume of leiomyoma.
