Influence of dexmedetomidine-assisted general anesthesia on hemodynamics,anesthetic dosage and postoperative sedation and analgesia in patients with radical gastrectomy for gastric cancer
10.7619/jcmp.201711026
- VernacularTitle:右美托咪定辅助全身麻醉对胃癌根治术患者围麻醉期血流动力学、麻醉药用量及术后镇静镇痛的影响
- Author:
Yahong WANG
1
;
Zhiyong LYU
;
Zhonghui WANG
;
Liang MA
;
Guangshun LIU
Author Information
1. 云南省肿瘤医院 麻醉科
- Keywords:
gastric cancer;
dexmedetomidine;
sedative and analgesic;
anesthetic dosage;
hemodynamics
- From:
Journal of Clinical Medicine in Practice
2017;21(11):87-89,93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore influence of dexmedetomidine-assisted general anesthesia on hemodynamics,anesthetic dosage and postoperative sedation and analgesia in patients with radical gastrectomy for gastric cancer.Methods A total of 50 patients with gastric cancer were randomly divided into experimental group and control group.The experimental group was treated with dexmedetomidine before anesthesia induction,while control group was treated with the same volume of normal saline.Heart rate,mean arterial pressure,bispectral index were recorded at the time points of exploration,immediately after extubation,skin incision,before injection,immediately before intubation,before induction of anesthesia,duration of anesthesia,1 min after intubation,and doses of remifentanil and propofolwere compared,and VAS and sedation score 1 and 4 h were compared.Results Before induction of anesthesia,bispectral index of the experimental group was significantly lower than the control group (P<0.01).At the time points of induction of general anesthesia,1 min after intubation,skin incision,exploration,extubation,the mean arterial blood pressure in experimental group decreased significantly (P<0.05),and the heart rate reduced significantly (P<0.01).The dosages of remifentanil and propofol in the experimental group were significantly lower than those in the control group.The sedation scores 1 and 4 h in the experimental group were significantly higher than the control group,and the VAS score was significantly lower than the control group (P<0.05).Conclusion Dexmedetomidine can reduce the hemodynamic changes and maintain the stability of the patients during tracheal intubation and general anesthesia induction.
