Correlation between hemorrhage and application of tranexamic acid in patients with cardiac surgery under extraorporeal circulation
10.7619/jcmp.201711021
- VernacularTitle:氨甲环酸与体外循环下心脏手术患者出血的相关性
- Author:
Zhina LIU
1
;
Yanping BAI
;
Bin HU
Author Information
1. 延安大学附属医院
- Keywords:
tranexamic acid;
extracorporeal circulation;
cardiac surgery;
bleeding;
blood transfusion
- From:
Journal of Clinical Medicine in Practice
2017;21(11):69-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study and analyze the correlation between hemorrhage in patients underwnet cardiac surgery under extracorporeal circulation and the application of tranexamic acid.Methods A total of 185 patients treated with cardiac surgery under extracorporeal circulation were selected and divided into observation group (tranexamic acid were employed in the surgery,n=81) and the control group (tranexamic acid were not employed in the surgery,n=104).The common blood indexes and the blood coagulation indexes levels of hematocrit (HCT),the platelet count (PLT),the prothrombin time (PT),the activated partial prothrombin time (APTT),the fibrinogen (FIB) of the patients before the surgery and at 24 h after the surgery were detected and compared.The extracorporeal circulation time,the aortic clamping time,the heparin application amount in surgery,the protamine application amount in surgery of the patients were recorded and compared.The bleeding amount,the transfusion amount of concentrated red blood cells,the transfusion amount of plasma,the transfusion amount of platelet before the surgery and at 24 h after the surgery as well as the reoccurrence of thoracic surgery due to bleeding of the patients in the two groups were observed and compared.The incidence of acute renal failure,renal failure,neurological complications,low cardiac output syndrome,twice intubation,pulmonary infection and the hospitalization mortality of the patients in the two groups were observed and compared.Results The HCT,PLT,FIB levels at 24 h after the surgery of the patients in the two groups were significantly lower than those before the surgery (P<0.05).The PLT level at 24 h after the surgery in the control group was significantly lower than that in the observation group (P<0.05).The bleeding amount,the transfusion amount of blood,the reoccurrence of thoracic surgery due to bleeding in the control group were significantly higher than those in the observation group (P<0.05).There were no significant differences of surgery related indexes between the two groups (P>0.05).There were no significant differences in incidence rates of postoperative complications and hospitalization mortality between the two groups (P>0.05).Conclusion The application of tranexamic acid in the cardiac surgery under extracorporeal circulation can effectively reduce the postoperative bleeding and blood transfusion volume,protect blood coagulation function.
