Effects of different concentrations of tacrolimus on treatment of patients with nephrotic syndrome
10.7619/jcmp.201711018
- VernacularTitle:不同血药浓度他克莫司对肾病综合征的疗效影响分析
- Author:
Yanzhi YU
1
;
Bingbing CAI
;
Wu GAO
Author Information
1. 湖北省随州市中心医院
- Keywords:
blood concentration;
tacrolimus;
nephrotic syndrome;
curative effect
- From:
Journal of Clinical Medicine in Practice
2017;21(11):59-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of different concentrations of tacrolimus on nephrotic syndrome.Methods A total of 90 kidney disease cases in our hospital from May 2012 to May 2016 were as research objects,the tacrolimus blood concentration was determined by ELISA method when blood concentration reached steady state after taking tacrolimus.All patients were followed up for 3 months to observe the efficacy,dosage and concentration of the drugs,and the incidence of adverse reactions was analyzed.Results After treatment,there were 76 cases with complete remission (84.4%),9 cases (10%) with partial remission,5 cases (5.6%) in invalid.The complete remission group,partial remission group and ineffective group dosage were (0.05±0.01) mg/(kg·d),(0.06±0.01) mg/(kg·d),and (0.07±0.02) mg/(kg·d),respectively.The concentration of drug in blood were (8.44±3.25) ng/mL,(5.92±1.53) ng/mL,and (3.34±0.86) ng/mL.Adverse reaction rates were 45.6% and 44.4% in complete remission group and partial remission group,which were significantly higher than 20.0% in the invalid group,the differences were statistically significant (P<0.05).Conclusion Different concentrations of tacrolimus have an effect on the treatment of nephrotic syndrome,the whole blood concentration of tacrolimus controlled in 5.19~11.69 ng/mL can reach satisfactory effect.
