A systematic study of 89Sr,bisphosphonates and 89Sr plus bisphosphonates therapy for patients with bone metastases
10.7619/jcmp.201711017
- VernacularTitle:89Sr、双膦酸盐及二者联合治疗肿瘤多发性骨转移的系统评价
- Author:
Jia GUO
1
;
Wenzhong SONG
Author Information
1. 四川省医学科学院
- Keywords:
89Sr;
89SrCl2;
bisphosphonates;
multiple bone metastases;
systematic assessment
- From:
Journal of Clinical Medicine in Practice
2017;21(11):54-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy of 89Sr,bisphosphonates and 89Sr plus bisphosphonates (combined therapy) for patients with bone metastases.Methods Authors searched MEDLINE,EMBASE,the Cochrane Library,CBMdisc and CNKI.Isotopes,Tumor,Chinese Journal of Nuclear Medicine and Molecular Imaging,Chinese Journal of Radiation Oncology were manually searched.Effects of 89Sr,bisphosphonates and combined therapy for bone metastases were analyzed.The quality of each study was evaluated.Meta-analysis was performed by RevMan 5.0 software.Results Totally 7 randomized controlled trials,1 semi-randomized controlled trial and 7 non-randomized controlled trials were selected (1196 patients).Compared with 89Sr and bisphosphonates,combined therapy was stronger in bone pain relief,improving life quality and decreasing lesions or reducing volume of bone metastases (P<0.01).Conclusion Combined therapy can relieve bone pain,improve life quality and decrease lesions or reduce volume of bone metastases.
