Value of apolipoprotein B/A-1 ratio combined with carotid plaque nature examination in predicting the risk of patients with coronary heart disease
10.7619/jcmp.201711011
- VernacularTitle:载脂蛋白B/A-1比值联合颈动脉斑块性质检查在冠心病患者危险性预测中的价值
- Author:
Jie CHU
1
;
Ping DU
;
Chen HE
;
Fangbing WANG
;
Yingping HAO
Author Information
1. 河北省张家口市建国医院
- Keywords:
carotid plaque;
apolipoprotein;
acute coronary syndrome;
coronary atherosclerotic cardiopathy
- From:
Journal of Clinical Medicine in Practice
2017;21(11):35-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of apolipoprotein B/A-1 ratio combined with carotid plaque nature examination in predicting the risk of patients with coronary heart disease.Methods A total of 250 patients with CHD were selected and divided into acute coronary syndrome group (ACS group,n=190) and stable angina pectoris group (SAP group,n=60).A total of 98 normal individuals by CAG were selected as control group.The carotid color ultrasound was performed for all the patients.The nature of carotid atherosclerostic plaque was estimated according to the acoustic characteristics of plaques.The ApoB and ApoA-1 contents as well as ApoB/A-1 ratio were detected and calculated,and correlations between indexes and risk factors were analyzed.Results There were no significant differences in levels of TC,TG,and LDL-C between the three groups (P>0.05).HDL-C level in the ACS group was significantly higher than that in the control group (P<0.05).ApoB and ApoB/A1 in the ACS group were significantly higher than those in the control group and ACS group (P<0.05).There was no significant difference in ApoA1 between the three groups (P>0.05).The total occurrence rates of plaques in ACS group and SAP group were significantly higher than the control group (P<0.05).The occurrence rate of carotid soft plaque in ACS group was significantly higher than SAP group and the control group (P<0.05).Conclusion Unstable plaques are able to detect by carotid ultrasound in CHD patients,and the ApoB level and ApoB/A-1 ratio increased abnormally,which indicates the severity of coronary artery lesions increases in CHD patients.
