Change and significance of bilateral frontal magnetic resonance spectroscopy in patients with Parkinson's disease and depression
10.7619/jcmp.201711007
- VernacularTitle:帕金森病抑郁患者双侧额叶的磁共振波谱改变及意义
- Author:
Bingqing CAO
1
;
Xin ZHANG
;
Kansheng HE
;
Bei KANG
;
Qian YANG
;
Tao WANG
Author Information
1. 陕西省人民医院
- Keywords:
Parkinson's disease;
Parkinson's disease depression;
magnetic resonance spectroscopy;
frontal
- From:
Journal of Clinical Medicine in Practice
2017;21(11):21-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change and significance of bilateral frontal magnetic resonance spectroscopy (1H-MRS) in patients with Parkinson's disease depression (DPD).Methods 1H-MRS for bilateral frontal lobe was performed in 20 patients with DPD,23 patients with PD and 20 healthy controls.The metabolite ratios of N-acetylaspartate (NAA)/Creatine(Cr) and Choline (Cho)/Cr in patients with PD and DPD and control group were compared.Results The NAA/Cr values of the first frontal lobe of patients with DPD were significantly lower than those of PD patients (P<0.05),while Cho/Cr values were significantly higher than those of PD patients (P<0.05).There were no significant differences of NAA/Cr and Cho/Cr values between DPD and PD patients.Conclusion 1H-MRS can detect the metabolic changes of frontal lobe in patients with DPD,and it can contribute to the diagnosis and risk prediction of DPD.
