Expression of uH2B in primary adenocarcinoma of the colon and its relationship with clinicopathological parameters
10.7619/jcmp.201709025
- VernacularTitle:uH2B在原发性结肠腺癌中的表达及其与临床病理参数的关系
- Author:
Haigang WANG
1
;
Hongmei XIE
;
Xue HAN
;
Lixian ZHANG
;
Wenzeng ZHAO
Author Information
1. 华北石油管理局总医院 普外二科
- Keywords:
primary adenocarcinoma of the colon;
generalization of histone H2B;
clinical pathological parameters
- From:
Journal of Clinical Medicine in Practice
2017;21(9):99-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study of primary colorectal adenocarcinoma histone H2B single prime generalization (uH2B) and its relationship with clinicopathological parameters.Methods Colonic canceRtissue samples and para-carcinoma tissue of gastrointestinal surgery resection of 83 cases were selected from January 2013 to January 2016 in ouRhospital,and normal colon tissue of 20 cases was collected,and uH2B protein expression level in tissue samples was observed using immunohistochemical staining,and its relationship with clinical pathological parameters of patients with primary colonic carcinoma was analyzed.Results The positive expression rate of uH2B protein in colon canceRtissues was 46.99%,which was loweRthan 83.13% of adjacent tissues and 90.00% in normal colon mucosa,the differences were statistically significant (P<0.05);But there was no significant difference in the positive expression of uH2B protein in adjacent tissues and normal colonic mucosa (P>0.05);The positive expression rate of tumoRuH2B protein in colon canceRtissues in the TNM stage was correlation with degree of differentiation and lymph node metastasis (P<0.05),and it had no significant relationship with the patient′s age,gender,tumoRinvasion depth,tumoRsize (P>0.05).Conclusion The decreased expression rate of uH2B protein in colon carcinoma tissue is correlated with the TNM stage,differentiation degree and lymph node metastasis of the patients.
