Effects of levetiracetam combined with topiramate on immune function and cognitive function in children with refractory epilepsy
10.7619/jcmp.201709019
- VernacularTitle:左乙拉西坦联合托吡酯对难治性癫痫患儿的免疫功能以及认知功能的影响
- Author:
Yujuan GAO
1
;
Pengke PAN
;
Ruihan WEI
;
Xiaoyang WEI
Author Information
1. 广西壮族自治区河池市人民医院
- Keywords:
intractable epilepsy;
levetiracetam;
topiramate;
immune function;
cognitive function
- From:
Journal of Clinical Medicine in Practice
2017;21(9):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of levetiracetam combined with topiramate on immune function and cognitive function in children with intractable epilepsy.Methods A total of 54 hospitalized children with intractable epilepsy were randomly divided into control group and combination group.All the children were treated with antiepileptic drugs,and the complications were prevented.The control group was treated with levetiracetam and the combination group was treated with topiramate.All the children were treated foR3 months.The levels of peripheral blood T lymphocyte subsets and immunoglobulin levels were detected by EEG analysis,and the cognitive function was evaluated.Results Compared with before treatment,levels of CD3+,CD4+ and CD4+/CD8+ increased significantly in both groups (P<0.05),CD8+ decreased significantly (P<0.05),and levels of serum IgA and IgG increased significantly (P<0.05).There were no significant changes in IgM and relative poweRof δ,α and β bands (P<0.05),and the relative poweRof the θ band decreased (P<0.05).Visual space and executive ability,attention and concentration,memory,calculation and orientation,and total scores increased significant (P<0.05),and scores of naming,language,abstract thinking did not change (P< 0.05).Compared with the control group,levels of CD3+,CD4+ and CD4+/CD8+ in the combined group were significantly higheR(P<0.05),CD8+ was significantly lower(P<0.05),levels of IgA,IgG were significantly higher(P<0.05),relative poweRreduction of the θ band were significantly lower(P<0.05),and visual space and executive ability,attention and concentration,memory,calculation and orientation and total score were significantly higheR(P<0.05),and the total effective rate was significantly higheR(P<0.05).Conclusion Levetiracetam combined with topiramate is effective in the treatment of intractable epilepsy in children,which can effectively improve the immune function and cognitive function.
