Clinical effect of high flux hemodialysis foRAECOPD patients complicated with renal insufficiency
10.7619/jcmp.201709006
- VernacularTitle:高通量透析对老年慢性阻塞性肺疾病急性加重期并肾功能不全患者的疗效观察
- Author:
Pinghong HE
1
;
Wenyong JIANG
;
Fengxian SU
;
Shanshan HU
;
Jingjing DA
;
Yan ZHA
Author Information
1. 贵州省人民医院
- Keywords:
high flux hemodialysis;
chronic obstructive pulmonary diseases;
acute exacerbation period;
clinical effect
- From:
Journal of Clinical Medicine in Practice
2017;21(9):24-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore effect comparison between high flux hemodialysis and conventional hemodialysis therapy on acute exacerbation chronic obstructive pulmonary diseases (AECOPD) patients with renal insufficiency.Methods Clinical data of 51 AECOPD combined renal insufficiency (BUN≥20 mmol/L,CREA≥400 μmol/L) cases admitted in ouRhospital and Guiyang First People′s Hospital from 2010 to 2015 were retrospectively analyzed.And were randomly divided into high flux hemodialysis (HFHD) group with 25 cases and conventional hemodialysis (CHD) group with 26 cases according to different dialysis method and dialysis,and the two groups before treatment all used the same internal medicine comprehensive treatment.Blood leukocyte count,neutrophil percentage,blood gas index[pH、SaO2、p(O2)],c-reactive protein (CRP) and interleukin-1 (IL-1),interleukin-6 (IL-6) and renal function (BUN and CREA) before and afteRtreatment were detected,and the difference of the above indexes before and afteRtreatment in both groups were compared.Results Leukocyte count,neutrophil percentage,CRP,IL-1,IL-6,BUN and CREA in two groups afteRtreatment were significantly decreased than treatment before (P<0.01),but HPHD group decreased more than CHD group (P<0.05).Blood and gas index in HPHD group and CHD group afteRtreatment fell,but there was no significant difference (P<0.05).Conclusion High flux hemodialysis (HPHD) has superioRcurative effect in the treatment of AECOPD and in removing inflammatory mediators,infection control,improving renal function,so it is worthy of clinical application.
