Clinical efficacy of different combined interventions in treatment of patients with malignant severe central airway stenosis
10.7619/jcmp.201707010
- VernacularTitle:不同联合介入方式治疗恶性中心气道重度狭窄患者的疗效观察
- Author:
Fang YAN
1
;
Zengrong YANG
;
Yu XIA
;
Kegang JIAO
Author Information
1. 新疆医科大学第一附属医院呼吸科
- Keywords:
malignant central airway stenosis;
high-frequency electrotome;
argon plasma coagulation;
freezing;
stent implantation
- From:
Journal of Clinical Medicine in Practice
2017;21(7):35-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of bronchoscope-guaided different combined interventions in the treatment of patients with malignant severe central airway stenosis.Methods A total of 48 patients with malignant severe central airway stenosis were selected and divided into group A treated with combined interventions including high-frequency electrotome + argon plasma coagulation (APC) + freezing (n =31),while another 17 with combined interventions including high-frequency electrotome + APC + freezing + tracheal stent implantation were designed as group B.The response rate (RR) after initial interventional treatment and the middle-and short-term clinical efficacy after 6-month follow up were observed,and corresponding complications and adverse events were recorded.Results The RR of all patients was 100％,in which group B was significantly better in the increase of airway diameter and increase rate of cross sectional area (CSA) (P ＜ 0.05),but was significantly lower in polypnea index than group A (P ＜ 0.05),but there was no significant difference between two groups in forced expiratory volume in one second (FEV1) in the expected value (FEV1％)(P ＞0.05).During 6-month follow-up,there were significant differences in the average monthly interventional therapeutic frequency and average remission period between two groups (P ＜0.05).No patients had complications immediately after interventional process.During the 6-month follow-up,4 8 patients had different-degree chest pain,hemoptysis and retention of secretes.Conclusion Bronchoscope-guided different combined interventions have excellent efficacy in the treatment of patients with malignant severe central airway stenosis.
