Expressions and significance of peripheral galectin-3 and N-terminal B-type brain natriuretic peptide in patients with chronic heart failure
10.7619/jcmp.201705007
- VernacularTitle:外周血半乳糖凝集素-3、N末端B型利钠肽原在慢性心力衰竭患者中的表达及意义
- Author:
Jiayun GU
1
;
Hailian XIA
;
Fangfang WANG
;
Yang ZHOU
;
Pei LIU
;
Yan TENG
Author Information
1. 江苏省南通市第三人民医院心电图室
- Keywords:
heart failure;
chronic;
Galectin-3;
N-terminal B-type brain natriuretic peptide
- From:
Journal of Clinical Medicine in Practice
2017;21(5):26-28,35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change of peripheral galectin (Gal)-3 and N-terminal B-type brain natriuretic peptide (NT-proBNP) in patients with chronic heart failure.Methods A total of 89 patients with chronic heart failure (CHF) were enrolled.Peripheral Gal-3,NT-proBNP were detected by enzyme-linked immunosorbent assay (ELISA) or Electrochemical luminescence method.The expression levels of Gal-3,NT-proBNP in patients with different kinds of heart failure and cardiac functional grading were analyzed.Results There were significant differences in expression levels of Gal-3 and NT-proBNP between patients with HFPEF and patients with HFREF.There was significant differences of Gal-3 and NT-proBNP in patients with NYHA heart function class Ⅱ,Ⅲ and Ⅳ.Gal3 was positively correlated with NT-proBNP (r =0.230,P =0.030) and negatively correlated with LVEF (r =-0.533,P =0.000).NT-proBNP was negatively correlated with LVEF (r =-0.372,P =0.000).Conclusion Peripheral Gal-3,NT-proBNP could be considered as two important markers for judging severity of illness in patients with CHF.
