Effect of inhaled corticosteroids guided by GLCCI1 gene detection on treatment of patients with asthma

VernacularTitle:哮喘患者GLCCI1基因检测指导吸入糖皮质激素的安全性用药效果
Author: Xingqiao WANG ¹ ; Qin YIN ; Tianqi WANG ; Wen HUANG ; Songming LI
Author Information

1. 湖北省中西医结合医院
Keywords: asthma; gene transcription induced by glucocorticoid 1; inhaled corticosteroids; budesonide aerosol
From: Journal of Clinical Medicine in Practice 2017;21(1):34-36
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical value of GLCCI1 gene detection in guiding administration of inhaled corticosteroids in patients with asthma.Methods Eighty asthma patients were divided into wild type allele group (n =64) and mutant type allele group (n =16) according to GLCCI1 gene detection.Both groups were treated with budesonide aerosol,and the clinical effect was compared between two groups.Results In wild type allele group,the total effective rate was 92.2％ and the incidence rate of adverse reaction was 7.8％,which were significantly better than 75.0％ and 25.0％ in mutant type allele group (P ＜ 0.05).There were significant differences in FEV1,FEV/FVC ratio,FVC and PEF between two groups (P ＜ 0.05).Conclusion The GLCCI1 gene detectiou can significantly improve the effect of inhaled corticosteroids and reduce the incidence rate of adverse reactions.