Value of Golgi protein 73 combined with phosphatidyl alcohol proteoglycans-3 detection in early diagnosis of primary liver cancer
10.7619/jcmp.201417007
- VernacularTitle:高尔基体蛋白73和磷脂酰基醇蛋白聚糖-3联合测定在原发性肝癌早期诊断中的价值
- Author:
Yanfeng WANG
1
;
Nanyang LI
;
Yaling REN
;
Xiubin XUE
;
Linchen LI
;
Leichun CAO
;
Ruyuan JIA
;
Xiaoping YU
Author Information
1. 河北省张家口市第一医院
- Keywords:
Golgi protein 73;
phosphatidyl alcohol proteoglycans-3;
primary liver cancer;
diagnostic value
- From:
Journal of Clinical Medicine in Practice
2014;(17):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of Golgi protein 73 (GP73 )combined with phosphatidyl alcohol proteoglycans-3 (GPC3 )detection in early diagnosis of primary liver cancer (PLC).Methods The serum GP73 and GPC3 levels were detected in 40 PLC patients,48 patients with liver cirrhosis,45 hepatitis patients and 44 healthy people by ELISA.Results Serum GP73 was (812.37±81.59)pg/mL and GPC3 was(89.27±12.38)ng/mL in PLC group,and GPC3, GP73 positive expression rate were 82.5%,87.5% respectively,which were significantly higher than the other 3 groups.GPC3 and GP73 levels,positive expression rate in liver cirrhosis patients and hepatitis patients were significantly higher than healthy control group.Sensitivity,specific de-grees and accuracy of GPC3 combined with GP73 detection were 92.5%,100% and 93.81%, which were significantly higher than those of GP73 ,GPC3 single test (P<0 .05 ).Conclusion GP73 combined with GPC3 detection can significantly improve the accuracy of PHC,which shows a high value in early diagnosis of PLC.
