Clinical effect of edaravone on treatment of patients with acute cerebral infarction and its influence on serum SOD and MDA
10.7619/jcmp.201417006
- VernacularTitle:依达拉奉治疗急性脑梗死患者的临床疗效及其对血清SOD、MDA水平的影响
- Author:
Huifen ZHENG
1
;
Huihua ZONG
;
Yan YU
;
Yanping ZHAO
Author Information
1. 南京医科大学附属脑科医院 老年神经科
- Keywords:
edaravone;
cerebral infarction;
free radical;
serum superoxide dismutase;
malondialdehyde
- From:
Journal of Clinical Medicine in Practice
2014;(17):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Obj ective To observe the clinical effect of edaravone on treatment of patients with acute cerebral infarction (ACI)and its influence on serum superoxide dismutase (SOD)and malondialdehyde (MDA).Methods A total of 64 ACI patients were randomly divided into control group (31 cases)treated with basic medicines and treatment group (33 cases)added with with edar-avone.Clinical efficacy,neurological function deficit improvement rate,American National Insti-tutes of Health Stroke Scale (NIHSS)and Barthel index (BI)as well as serum SOD and MDA level changes in both groups were observed.Results 14 d after treatment,the clinical efficacy in treat-ment group was 84.85%,significantly higher than the 61.29% in control group (P<0.01). NIHSS and Barthel scores were better after treatment than those before (P<0.01),and differences between two groups were also significant (P<0 .05 ).After treatment,SOD level was higher in treatment group (P<0 .0 1 )and lower in control group than those before treatment (P<0 .0 1 ), whereas MDA level was lower in treatment group (P<0 .0 1 )and higher in control group than those before treatment (P<0 .05 ).Additionally,there had no severe adverse responses in both groups. Conclusion On the basis of basic treatment,the application of edaravone has favorable clinical effi-cacy and safety in the treatment of ACI .
