Effects of Danhong inj ection on protection of brain in rats with acute cerebral infarction
10.7619/jcmp.201417002
- VernacularTitle:丹红注射液对大鼠急性脑梗死保护作用的实验研究
- Author:
Ye YU
1
;
Ian Dij SHI
;
Jianbo CHEN
Author Information
1. 重庆市第三人民医院 药学部
- Keywords:
Danhong inj ection;
rat;
cerebral ischemia;
acute cerebral infarction
- From:
Journal of Clinical Medicine in Practice
2014;(17):5-7
- CountryChina
- Language:Chinese
-
Abstract:
Obj ective To investigate the brain-protective mechanism of Danhong inj ection in rats with acute cerebral infarction.Methods 30 rats of acute cerebral infarction models was es-tablished by means of occlusion of middle cerebral artery and randomly divided into Sham-operation group,operation group and operation plus Danhong group,10 cases in each group.The superoxide dismutase (SOD),glutathion peroxidase (GSH-Px)activities and the malondiadehyde (MDA) content in the cerebral tissue were determined after 5 d.Meanwhile the neurological function,Brain water content and histopathologic examination were observed.Results The SOD and GSH-Px activities in the operation plus Danhong group increased obviously,while the MDA content de-creased significantly compared with the operation group (P<0 .0 1 ).Moreover,there were slighter pathological changes in brain tissues.Conclusion Danhong inj ection has a certain protective effects on damage of brain tissues,which is possibly related to increased SOD and GSH-Px activities,and decreased MDA content.
