Correlation of high expression of interleukin 22 with FOLFOX chemoresistant status in colorectal cancer patients
10.7619/jcmp.201416017
- VernacularTitle:结直肠癌患者血清中高表达白介素22与FOLFOX 化疗抵抗的相关性
- Author:
Tingyu WU
1
;
Yun LIU
;
Zhonglin LIANG
;
Zubing MEI
;
Guanghui WANG
;
Ang CUI
;
CUILong
;
Kejin WU
Author Information
1. 上海交通大学医学院附属新华医院 肛肠外科
- Keywords:
interleukin 22;
colorectal cancer;
5-fluorouracil;
oxaliplatin
- From:
Journal of Clinical Medicine in Practice
2014;(16):60-62,66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between IL-22 expression levels in serum and FOLFOX resistant status and to examine weather IL-22 could promote chemoresistance in colorec-tal cancer cells.Methods ELISA were preformed to detect IL-22 expression levels in 60 patients who received FOLFOX adjuvant chemotherapy after radical excision.The chemoresistant effect of IL-22 in colorectal cancer cells with treatment of chemotherapeutic drugs was investigated.Results IL-22 serum levels increased in chemoresistant patients compared with chemosensitive patients.In addi-tion,IL-22 could confer resistance to 5-FU and OXA of SW480 and SW620 cell lines.Conclusion Elevated serum IL-22 levels correlate with FOLFOX chemoresistant condition of colorectal cancer and may be an important factor for chemoresistance.
