Relationship between adiponectin,B-type natriuretic peptide,high sensitivity C-reactive protein and cardiac function classification in patients with degenerative heart valvular disease

VernacularTitle:退行性心瓣膜病患者心功能分级与脂联素、脑钠肽、超敏C反应蛋白的关系
Author: Hualan ZHOU ¹ ; Youdong HU ; Dianxuan GUO ; Xia LI ; Peijing XU
Author Information

1. 徐州医学院附属淮安医院老年科
Keywords: degenerative heart vascular disease; adiponectin; B-type natriuretic peptide; high sensitivity C-reactive protein
From: Journal of Clinical Medicine in Practice 2014;(16):25-27
CountryChina
Language:Chinese
Abstract: Objective To evaluate the serum levels of adiponectin(APN),B-type natri-uretic peptide(BNP),high sensitivity C-reactive protein (hs-CRP)and their clinical significance in patients with degenerative heart vascular disease (DHVD )according to different cardiac function classification.Methods According to New York Heart Association(NYHA),132 patients with DHVD were divided into NYHA class Ⅰ group(A group),NYHA class Ⅱ group (B group),NY-HA class Ⅲ group (C group),NYHA class Ⅳ group (D group).The serum levels of APN , BNP,hs-CRP were measured,left ventricular ejection fraction (LVEF)were determined by Doppler spectrum analysis.Results The serum levels of APN,BNP and hs-CRP levels signifi-cantly increased in patients with a higher class of NYHA (P <0.01).The serum APN,BNP and hs-CRPlevelswerenegativelycorrelatedwithLVEFinallpatients (r = -0 .3 6 ,P <0 .0 1 ;r =-0.42,P <0.01;r =-0.39,P <0.01).Conclusion The serum APN,BNP and hs-CRP levels are helpful in evaluating the changes in cardiac function of DHVD.