Pim-1: A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis.
- Author:
Zeping WANG
1
;
Nandini BHATTACHARYA
;
Matt WEAVER
;
Kate PETERSEN
;
Maria MEYER
;
Leslie GAPTER
;
Nancy S MAGNUSON
Author Information
1. School of Molecular Biosciences Washington State University Pullman, Washington 99164-4234, USA. magnuson@mail.wsu.edu
- Publication Type:Original Article ; Review
- MeSH:
Animals;
Apoptosis/*physiology;
Cell Differentiation/physiology;
Cell Division/*physiology;
*Cell Transformation, Neoplastic;
Gene Expression Regulation, Enzymologic;
Humans;
Lymphoma/etiology;
Mice;
Protein-Serine-Threonine Kinases/genetics/*physiology;
Proto-Oncogene Proteins/genetics/*physiology;
Proto-Oncogene Proteins c-pim-1;
Signal Transduction
- From:Journal of Veterinary Science
2001;2(3):167-179
- CountryRepublic of Korea
- Language:English
-
Abstract:
Pim-1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from moloney murine leukemia virus (MuLV)-induced T-cell lymphomas in mice, Pim-1 kinase is involved in the control of cell growth, differentiation and apoptosis. Expression of Pim-1 kinase can be stimulated by a variety of growth factors and regulated at four different levels: transcriptional, post-transcriptional, translational and post-translational. Several signal transduction pathways may be associated with the regulation of Pim-1's expression; accumulating data support that the expression of Pim-1 protein is mediated through activation of JAK/STATs. Recent studies of Pim family kinases indicate that Pim-1 kinase plays important roles outside of the hematopoietic system as well.
