Effect of small dose of fentanyl combined with midazolam on prevention of radial artery spasm during transradial coronary intervention
10.7619/jcmp.201409023
- VernacularTitle:经桡动脉行冠状动脉介入过程中小剂量芬太尼联合咪唑安定预防桡动脉痉挛的临床效果
- Author:
Minghui LI
1
;
Yuan BAI
;
Hongwen TAN
;
Xiang CHEN
;
Xhigang XHANG
;
Yongwen QIN
Author Information
1. 第二军医大学长海医院 心血管内科
- Keywords:
fentanyl;
midazolam;
percutaneous coronary intervention;
radial artery spasm
- From:
Journal of Clinical Medicine in Practice
2014;(9):82-84
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of small dose of fentanyl combined with midazo-lam on prevention of radial artery spasm.Methods 1086 patients with elective transradial percuta-neous coronary intervention were randomly divided into medicine group and control group.The medicine group was treated with conventional intravenous injection of fentanyl and midazolam.Inci-dence rate of radial spasm,vascular complications and mortality rate or re-hospitalization rate with-in 30 days were recorded and compared between two groups.Results Incidence rate of radial spasm in medicine group was 2.5%,which was significantly lower than 8.8% in the control group (P <0.001).There were no significant differences in aspects of VAS score,mortality rate and re-hos-pitalization rate between two groups.Multivariate analysis showed that there were obvious correla-tion between incidence of radial spasm and gender,height,obesity,smoking,numbers of tubes, surgical way and difficulty of operation.Conclusion Small dose of fentanyl combined with midazo-lam during transradial interventional procedures can significantly reduce the incidence of radial spasm and vascular complications,and it won’t cause increasing of mortality rate and re-hospitalization rate.
