Omega 3 fatty acids as a host modulator in chronic periodontitis patients: a randomised, double-blind, palcebo-controlled, clinical trial.
10.5051/jpis.2014.44.1.25
- Author:
Girish D DEORE
1
;
Abhijit N GURAV
;
Rahul PATIL
;
Abhijeet R SHETE
;
Ritam S NAIKTARI
;
Saurabh P INAMDAR
Author Information
1. Department of Periodontology, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India. periogiri86@gmail.com
- Publication Type:Clinical Trial ; Randomized Controlled Trial ; Original Article
- Keywords:
Chronic periodontitis;
C-reactive protein;
Omega-3 fatty acids
- MeSH:
Alveolar Bone Loss;
Arthritis, Rheumatoid;
Bacteria;
C-Reactive Protein;
Cardiovascular Diseases;
Chronic Periodontitis*;
Communicable Diseases;
Dietary Supplements;
Fatty Acids, Omega-3*;
Hemorrhage;
Humans;
Inflammation;
Periodontal Index;
Periodontitis;
Root Planing
- From:Journal of Periodontal & Implant Science
2014;44(1):25-32
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Periodontitis is an infectious disease caused predominantly by gram-negative anerobes. The host inflammatory response to these bacteria causes alveolar bone loss that is characterized as periodontitis. Omega-3 fatty acids (omega-3 FAs) have anti-inflammatory properties, thus have been used to treat some chronic inflammatory diseases such as cardiovascular disease and rheumatoid arthritis. We aimed to evaluate the effect of dietary supplementation with omega-3 FAs as a host modulating agent in patients with chronic periodontitis. METHODS: Sixty otherwise healthy subjects with moderate and severe chronic periodontitis were enrolled in our randomised, double-blind, placebo-controlled trial. The control group (CG, n=30) was treated with scaling and root planing (SRP) and given a placebo; the treatment group (TG, n=30) was treated with SRP and dietary supplementation of omega-3 FAs (one 300 mg tablet daily for 12 weeks). Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluated in all patients at baseline, a 6-week and 12-week period after treatment. RESULTS: A significant reduction in the gingival index, sulcus bleeding index, pocket depth, and clinical attachment level was found in the TG compared to the CG at a 12-week period. However, no statistically significant changes in serum CRP levels were found. CONCLUSIONS: Our findings suggest that omega-3 FAs can successfully reduce gingival inflammation, pocket depth, and attachment level gain. Dietary supplementation with omega-3 FAs may have potential benefits as a host modulatory agent in the prevention and/or adjunctive management of chronic periodontitis.
