Research progress on histone acetylation modification in the aging of mesenchymal stem cells

VernacularTitle:组蛋白乙酰化修饰在间充质干细胞衰老中的研究进展
Author: Min JIANG ¹ ; You ZHOU ; Wei XIONG ; Shu GUO
Author Information

1. 中国医科大学临床医学专业，沈阳　110001
Keywords: Aging; Mesenchymal stem cells; Histones; Histone acetylation modification
From: Chinese Journal of Plastic Surgery 2024;40(11):1242-1248
CountryChina
Language:Chinese
Abstract: The decline in the regenerative capacity of tissues and organs due to aging is significantly attributed to the failure of mesenchymal stem cells (MSCs). Changes in histone acetylation levels are a key mechanism underlying the biological characteristics of aging MSCs. Targeted repair of abnormal histone acetylation in aging MSCs holds promise as an effective treatment for anti-aging therapy. This article reviews the roles of histone acetylases and histone deacetylases in the aging process of MSCs, aiming to provide new insights for anti-aging therapy.