Advances in tumor microenvironment and immunotherapy for melanoma
10.3760/cma.j.cn114453-20231102-00181
- VernacularTitle:黑色素瘤的肿瘤微环境及免疫治疗研究进展
- Author:
Rongyao SUN
1
;
Xinxin LI
;
Tonghao YAO
;
Xu MA
Author Information
1. 哈尔滨医科大学附属第二医院整形外科，哈尔滨 150086
- Keywords:
Melanoma;
Tumor microenvironment;
Immunotherapy;
Immunosuppression;
Immune checkpoint inhibitors
- From:
Chinese Journal of Plastic Surgery
2024;40(10):1142-1148
- CountryChina
- Language:Chinese
-
Abstract:
Melanoma is a malignant skin tumor characterized by a propensity for early metastasis and high mortality rates. Immune checkpoint inhibitors have significantly improved the prognosis for melanoma patients, however, some individuals remain unresponsive to immunotherapy, primarily due to the immunosuppressive characteristics of the tumor microenvironment. This review summarizes recent research on the melanoma tumor microenvironment and analyzes how dynamic changes in its components influence melanoma development and the efficacy of immunotherapy. Additionally, it outlines immunotherapy strategies focused on immune checkpoint inhibitors, examines their mechanisms of action and limitations, and further investigates the effects of combining immune checkpoint inhibitors with various therapeutic modalities, including radiotherapy, chemotherapy, and targeted therapies. This study aims to provide new insights into the melanoma tumor microenvironment and the advancement of personalized precision immunotherapy.
