Mechanism and application of stem cell-derived apoptotic bodies in regulating tissue regeneration
10.3760/cma.j.cn114453-20231101-00176
- VernacularTitle:干细胞凋亡小体调控组织再生的机制与应用
- Author:
Yufan ZHU
1
;
Xihang CHEN
;
Yunjun LIAO
Author Information
1. 南方医科大学南方医院整形外科，广州 510515
- Keywords:
Stem cells;
Apoptotic bodies;
Tissue regeneration;
Drug delivery carrier
- From:
Chinese Journal of Plastic Surgery
2024;40(9):1018-1025
- CountryChina
- Language:Chinese
-
Abstract:
Apoptotic bodies (ApoBDs) therapy is a novel and promising cell-free therapeutic strategy. However, the therapeutic mechanism and application of stem cells derived ApoBDs in tissue regeneration have not yet received adequate attention and research evidence. This review summarized the physiological and pathological effects, formation, release, enrichment and purification process of ApoBDs in detail. Furthermore, this review introduced the possible mechanism researches of stem cell-derived ApoBDs regulating regeneration of different organs and tissues, evaluated the possible strategies for their applications as drug delivery carrier, and prospected the development of the engineered modified ApoBDs in regenerative medicine.
