The influence of different parts of the human body and individual differences on adipose tissue and mesenchymal stem cells
10.3760/cma.j.cn114453-20221105-00349
- VernacularTitle:人体不同部位和个体差异对脂肪组织及其间充质干细胞的影响
- Author:
Qiang YUE
1
;
Liqiang LIU
Author Information
1. 中国医学科学院北京协和医学院整形外科医院会阴整形与性别重塑科，北京 100144
- Keywords:
Adipose tissue;
Adipose-derived mesenchymal stem cells;
Obesity;
Cell function;
Metabolic reprogramming
- From:
Chinese Journal of Plastic Surgery
2024;40(8):917-923
- CountryChina
- Language:Chinese
-
Abstract:
Adipose tissue is not only an important endocrine organ but also a regional immune system. Adipose derived mesenchymal stem cells (ADSCs) are hot spots in regenerative medicine and fat transplantation in recent years. However, the imbalance of regional immune homeostasis and metabolism may effect adipose tissue function through metabolic reprogramming and other mechanisms, resulting in differences in adipocytes from various parts and individuals. Plastic surgeons have always been concerning on the best donor site and individual of fat harvest, but there are still major controversies in this area, limiting the clinical application of adipose and ADSCs. This paper compared the differences of adipose tissue in different parts of the human body, analyzed the effects of different individual factors on adipose tissue function, possible reasons and metabolic reprogramming mechanism, and provided a reference for better exploration of fat metabolism function and clinical application of ADSCs.
