Research progress on the pre-treatment and engineering modification of mesenchymal stem cell-derived exosomes in chronic wound repair
10.3760/cma.j.cn114453-20231228-00276
- VernacularTitle:间充质干细胞外泌体预处理及工程化改造在慢性创面修复中的研究进展
- Author:
Yunlong LI
1
;
Xi HUANG
;
Yanbiao ZHANG
;
Hongfei DONG
;
Wei XUE
;
Bo HUANG
;
Xianhui LI
Author Information
1. 西部战区总医院烧伤整形外科，成都 610083
- Keywords:
Stem cells;
Mesenchymal stem cells;
Exosomes;
Wounds and injuries;
Biomedical engineering
- From:
Chinese Journal of Plastic Surgery
2024;40(7):709-717
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, studies have shown that exosomes can replace mesenchymal stem cell for chronic wound repair. However, exosomes have some problems such as poor targeting, low availability and low yield, so it has limited effect in the treatment of chronic wound. Maximizing the therapeutic benefits of exosomes is the primary challenge that needs to be overcome when used for chronic wound repair. Studies have shown that the treatment potential of exosomes can be further developed by pretreatment and engineering modification of exosomes. This article reviewed the research progress of exosome pretreatment and engineering modification in chronic wound repair, and provided reference for subsequent research and clinical application.
