Advancements in research on natural biomaterials promoting mesenchymal stem cell adipogenic differentiation
10.3760/cma.j.cn114453-20231022-00090
- VernacularTitle:天然生物材料促进间充质干细胞成脂分化的研究进展
- Author:
Yidan XU
1
;
Yao YAO
;
Jianhua GAO
Author Information
1. 南方医科大学南方医院整形外科，广州 510515
- Keywords:
Tissue engineering;
Natural biomaterials;
Mesenchymal stem cells;
Adipogenic differentiation;
Adipose tissue engineering
- From:
Chinese Journal of Plastic Surgery
2024;40(5):576-581
- CountryChina
- Language:Chinese
-
Abstract:
Tissue engineering achieves tissue repair and regeneration through the utilization of three essential components: stem cells, scaffold materials, and growth factors. Inducing the adipogenic differentiation of mesenchymal stem cells (MSCs) and constructing engineered adipose tissue represent innovative strategies for addressing soft tissue defects within the field of plastic surgery. Natural biomaterials exhibit physicochemical properties resembling those of the extracellular matrix, thereby fostering the proliferation and differentiation of stem cells. These natural biomaterials serve as suitable scaffold materials for tissue engineering applications. This review provided a comprehensive summary of the characteristics of various natural biomaterials, including decellularized matrix, extracellular matrix derivatives, filamentous proteins, alginate, chitosan, and bacterial cellulose. It further offered a review of research studies pertaining to their capacity to induce adipogenic differentiation in MSCs, thereby offering insights for the selection of materials in subsequent investigations.
