Research progress on the mechanism of mechanical tension affecting wound heeling in different periods
10.3760/cma.j.cn114453-20211021-00412
- VernacularTitle:机械牵张力对创面愈合瘢痕形成不同时期影响机制研究进展
- Author:
Wenhan ZHANG
1
;
Yang AN
;
Zhenmin ZHAO
Author Information
1. 北京大学第三医院成形外科，北京 100191
- Keywords:
Wound healing;
Mechanical tension;
Signal transduction;
Pathological scar
- From:
Chinese Journal of Plastic Surgery
2024;40(2):243-248
- CountryChina
- Language:Chinese
-
Abstract:
The formation of pathological scar has an impact on patients’ normal life and mental health, which is also a thorny problem in plastic surgery. In recent years, the influence mechanism of mechanical tension and signal transduction on wound healing has attracted extensive attention and provides a new idea for the prevention and treatment of pathological scar. This paper reviews the research progress of the influence mechanism of mechanical stretch on wound healing in different stages. In the inflammatory stage, hyperplasia stage and tissue remodeling stage of wound healing, mechanical stretch tension causes biological reactions such as chronic inflammation, fibrosis, angiogenesis, and extracellular matrix remodeling through complex signal transduction and feedback mechanisms, which has an impact on wound healing and scar formation. Mechanical stretch therapy for wound healing and scar formation has also achieved certain result in clinical and basic study.
